関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Butyric Acid | HCID 264 | — |
| 反応物 | Resorcinol | HCID 5054 | — |
| 反応物 | Hydrochloric acid brine | HCID 131718760 | — |
| 触媒 | Zincchloride | HCID 3007855 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | 4-Butanoylresorcinol | HCID 78103 | — |
反応手順
To a solution of resorcinol (1.5 g) and butyric acid (2.9 mL) in 1,2-dichloroethane (45 mL) was added ZnCl2 (3.22 g) and the mixture then heated at 150° C. under nitrogen for 5 hr. The reaction mixture was cooled, poured onto 1N HCl/brine and extracted (3x EtOAc). After washing with 0.1N K2CO3, then twice with brine, the organic layer was dried and evaporated. Chromatography of the residue (silica gel; hexane/EtOAc 2:1) afforded the title product as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05360815 |
|---|
| 出典データセット | uspto-grants-1994_11 |
|---|
| ORD ID | ord-bf0c04924124472d9d82c72dd027406c |
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| 出典メモ | uspto-grants-1994_11 |
|---|
