Terazosin Hydrochloride → Terazosin

HRID 2379401

反応式

HRID 2379401 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]2[C:9]([NH2:26])=[N:10][C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([CH:21]4[O:25][CH2:24][CH2:23][CH2:22]4)=[O:20])[CH2:15][CH2:14]3)=[N:12][C:6]2=[CH:5][C:4]=1[O:27][CH3:28].O.O.Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]2[C:9]([NH2:26])=[N:10][C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([CH:21]4[O:25][CH2:24][CH2:23][CH2:22]4)=[O:20])[CH2:15][CH2:14]3)=[N:12][C:6]2=[CH:5][C:4]=1[O:27][CH3:28]

参加物

3

反応物 1

HCID 63016Terazosin Hydrochloride

生成物 1

HCID 5401Terazosin

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Terazosin monohydrochloride dihydrate (620 mg, 1.35 mmol) was dissolved in 100 mL of hot absolute ethanol in a 250 mL Erlenmeyer flask fitted with a ground glass joint. The solution was slowly cooled to room temperature and allowed to stand overnight. The resulting white crystalline precipitate was collected by vacuum filtration to yield 100 mg (0.24 mmol, 17.4%) of the anhydrous crystalline polymorph of terazosin of this invention. The material was found by its powder x-ray diffraction pattern to be free of both the prior art anhydrous crystalline modification and the dihydrate form.

後処理

  1. customfitted with a ground glass joint
  2. filtrationThe resulting white crystalline precipitate was collected by vacuum filtration

出典と根拠

ORDレコード
ord-d59d9fb764014b84b9b64fb74483d498
出典データセット
uspto-grants-1994_11
特許番号
US05362730

関連ノート

読み込み中…