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1,2-Dichlorobenzene → 1-Fluoro-2-nitronaphthalene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 反応物 | 2-Nitronaphthalen-1-amine | HCID 136403 | — |
| 反応物 | Nitrilooxonium tetrafluoroborate | HCID 11137142 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Fluoro-2-nitronaphthalene | HCID 22008471 | — |
反応手順
To a well stirred slurry of nitrosonium tetrafluoroborate (Aldrich) (10 % molar excess, (cf. David J. Milner, Synthetic Communications (1992) 22 (1), 73-82.)) in dichloromethane at 0° C. is added 1-amino-2-nitronaphthalene. After 30 minutes, ortho-dichlorobenzene is added and the dichloromethane is distilled off, and the dichlorobenzene is heated at 50°-200 ° C. to decompose the diazonium tetrafluoroborate. Removal of solvent and purification of the product by chromatography or crystallization yields 1-fluoro-2-nitronaphthalene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05362747 |
| 出典データセット | uspto-grants-1994_11 |
| ORD ID | ord-d9497c760e6047559109574ac42038e4 |
| 出典メモ | uspto-grants-1994_11 |