4-(3,4-Dichlorophenyl)-4-piperidinol → 1-{3-(3,4-Dichlorophenoxy)propyl}-4-hydroxy-4-(3,4-dichlorophenyl)piperidine

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[Cl:13])[O:5][CH2:6][CH2:7][CH2:8]Cl.[OH:14][C:15]1([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=2)[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[Cl:13])[O:5][CH2:6][CH2:7][CH2:8][N:18]1[CH2:19][CH2:20][C:15]([OH:14])([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=2)[CH2:16][CH2:17]1

参加物

反応物 2

HCID 186757284-(3,4-Dichlorophenyl)-4-piperidinol

HCID 187686363-(3,4-Dichlorophenoxy)propylchloride

生成物 1

HCID 189573321-{3-(3,4-Dichlorophenoxy)propyl}-4-hydroxy-4-(3,4-dichlorophenyl)piperidine収率 97.5%

実験手順

3-(3,4-dichlorophenoxy)propylchloride 1.38 g and 4-hydroxy-4-(3,4-dichlorophenyl)piperidine 1.35 g are reacted in the same manner as Example 109 (1) to prepare 2.40 g (Yield: 97.5%) of 1-{3-(3,4-dichlorophenoxy)propyl}-4-hydroxy-4-(3,4-dichlorophenyl)piperidine (III-66). mp. 118.0°-118.5° C.

出典と根拠

ORDレコード: ord-2b411f0316d24ec8972e104fb2fd525d
出典データセット: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05362873

反応ノート

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