HCID 86747712、化合物 → HCID 18957438、化合物
反応式
[CH3:1]/[C:2](/[CH2:16][CH2:17]/[CH:18]=[C:19](\[CH3:26])/[CH2:20][CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24])=[CH:3]\[CH2:4][CH2:5][S:6][CH2:7][P:8](=[O:15])([O:12]CC)[O:9]CC>C1(C)C=CC=CC=1>[CH3:1]/[C:2](/[CH2:16][CH2:17]/[CH:18]=[C:19](\[CH3:26])/[CH2:20][CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24])=[CH:3]\[CH2:4][CH2:5][S:6][CH2:7][P:8](=[O:9])([OH:12])[OH:15]参加物
3
実験手順
Diethyl [(E,E)-4,8,12-trimethyl-3,7,11 -tridecatrienyl]thiomethylphosphonate (0.256 g, 0.636 mmol) was deprotected in a similar fashion as that described in Step 2 of Example 2. The reaction mixture was added toluene (3 mL), then evaporated in vacuo. This process was repeated two more times. The final residue was treated with diluted hydrochloride acid (0.1N) at 0° C., then extracted with ethylacetate. The extract was washed with water the three time (3×10 ML). After drying and filtration, filtrate was concentrated in vacuo to give the title compound (0.1 g, 0.29 mmol, 45%) as a gum.
後処理
- customevaporated in vacuo
- additionThe final residue was treated with diluted hydrochloride acid (0.1N) at 0° C.