[2-(4-Bromomethyl-phenyl)-2-methyl-propoxy]-tert-butyl-dimethyl-silane → (3-{[{4-[2-(tert-Butyl-dimethyl-silanyloxy)-1,1-dimethyl-ethyl]-benzyl}-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid tert-butyl ester

HRID 23796

反応式

HRID 23796 の反応式
[C:1]([O:5][C:6](=[O:26])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16][S:17]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)(=[O:19])=[O:18])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Br[CH2:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]([CH3:46])([CH3:45])[CH2:36][O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:40])[CH3:39])=[CH:31][CH:30]=1>>[C:1]([O:5][C:6](=[O:26])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]([CH2:28][C:29]2[CH:30]=[CH:31][C:32]([C:35]([CH3:46])([CH3:45])[CH2:36][O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:39])[CH3:40])=[CH:33][CH:34]=2)[S:17]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)(=[O:19])=[O:18])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 22590501[2-(4-Bromomethyl-phenyl)-2-methyl-propoxy]-tert-butyl-dimethyl-silaneHCID 69730626{3-[(Pyridine-3-sulfonylamino)-methyl]-phenoxy}-acetic acid tert-butyl ester

生成物 1

HCID 69729909(3-{[{4-[2-(tert-Butyl-dimethyl-silanyloxy)-1,1-dimethyl-ethyl]-benzyl}-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid tert-butyl ester

実験手順

The title compound was prepared by alkylation of {3-[(pyridine-3-sulfonylamino)-methyl]-phenoxy}-acetic acid tert-butyl ester (122 mg, 0.322 mmol) with [2-(4-bromomethyl-phenyl)-2-methyl-propoxy]-tert-butyl-dimethyl-silane (121 mg, 0.339 mmol) following the procedure described for Example 1, Step A. The reaction time was 1 h. The crude product (238 mg) was used in the next step without purification. MS 655 (M+1).

後処理

  1. customThe crude product (238 mg) was used in the next step without purification

出典と根拠

ORDレコード
ord-a1b03d1712dd49f2bbd9af9fca405b29
出典データセット
uspto-grants-2005_02
特許番号
US06852863B2

関連ノート

読み込み中…