Ammonia → 3-Pyridinecarboxamide, 5-acetyl-

反応式

C[O:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[C:9]([C:11](=[O:13])[CH3:12])[CH:10]=1)=O.[NH3:14]>>[C:11]([C:9]1[CH:8]=[N:7][CH:6]=[C:5]([C:3](=[O:2])[NH2:14])[CH:10]=1)(=[O:13])[CH3:12]

参加物

反応物 2

HCID 222Ammonia

HCID 596459Methyl 5-acetylpyridine-3-carboxylate

生成物 1

HCID 226073883-Pyridinecarboxamide, 5-acetyl-

実験手順

A suspension of 5-acetyl-3-pyridinecarboxylic acid methyl ester (5.0 g) in 28% ammonia solution (30 ml) was stirred at room temperature for 2 hours. The resulting precipitate was collected by filtration to afford 3-acetyl-5-carbamoylpyridine (3.38 g).

後処理

filtrationThe resulting precipitate was collected by filtration

出典と根拠

ORDレコード: ord-d1cd05bb777243bc8999f460bbe1c019
出典データセット: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05364871

反応ノート

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