Amidinothiourea → 4-(2-Acetylaminomethylthiazol-5-yl)-2-(diaminomethyleneamino)thiazole dihydrobromide
反応式
[C:1]([NH:4][CH2:5][C:6]1[S:7][C:8]([C:11](=O)[CH2:12][Br:13])=[CH:9][N:10]=1)(=[O:3])[CH3:2].[NH2:15][C:16](=[N:18][C:19]([NH2:21])=[S:20])[NH2:17]>CC(C)=O>[BrH:13].[BrH:13].[C:1]([NH:4][CH2:5][C:6]1[S:7][C:8]([C:11]2[N:21]=[C:19]([N:18]=[C:16]([NH2:17])[NH2:15])[S:20][CH:12]=2)=[CH:9][N:10]=1)(=[O:3])[CH3:2]参加物
4
実験手順
A mixture of 2-acetylaminomethyl-5-bromoacetylthiazole (6.30 g) and diaminomethylenethiourea [(H2N)2C=NCSNH2 ] (1.77 g) in acetone (90 ml) was refluxed for 10 hours with stirring. The resulting precipitate was collected by filtration to give 4-(2-acetylaminomethylthiazol-5-yl)-2-(diaminomethyleneamino)thiazole dihydrobromide (2.21 g).
後処理
- temperaturewas refluxed for 10 hours
- filtrationThe resulting precipitate was collected by filtration
出典と根拠
- ORDレコード
- ord-a95a7dab38524d37870975116e2bb7f8
- 出典データセット
- uspto-grants-1994_11
- 特許番号
- US05364871
反応ノート
読み込み中…