Triethylamine → HCID 178485206、化合物

HRID 2379853ノート

反応式

HRID 2379853 の反応式
Cl.Cl.Cl.[NH2:4][CH2:5][C:6]1[N:11]=[C:10]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=2)[CH:9]=[CH:8][CH:7]=1.[CH2:21]([N:23]([CH2:26]C)CC)C.[CH3:28][S:29]([N:32]=C(SC)SC)(=[O:31])=[O:30]>C(O)C>[NH2:19][C:18](=[N:17][C:14]1[S:15][CH:16]=[C:12]([C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([CH2:5][NH:4][C:21]([NH:23][CH3:26])=[N:32][S:29]([CH3:28])(=[O:31])=[O:30])[N:11]=2)[N:13]=1)[NH2:20]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 13449843N-[bis(methylsulfanyl)methylidene]methanesulfonamideHCID 189538374-(6-Aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole trihydrochloride

生成物 1

HCID 178485206HCID 178485206、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole trihydrochloride (1.5 g), triethylamine (1.8 ml) and dimethyl N-methanesulfonyldithiocarbonimidate (0.8 g) in ethanol (30 ml) was heated under reflux for 5 hours. The solvent was removed by concentration in vacuo. To the residue was added to a mixture of 40% aqueous methylamine (4.0 ml) in N,N-dimethylformamide (13 ml) and the mixture was stirred at ambient temperature for 30 hours. The reaction mixture was added a water and the isolated precipitate was collected by filtration to give 2-(diaminomethyleneamino)-4-[6-(2-methanesulfonyl-3-methylguanidino)methylpyridin-2-yl]thiazole (1.12 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. customThe solvent was removed by concentration in vacuo
  4. additionTo the residue was added to a mixture of 40% aqueous methylamine (4.0 ml) in N,N-dimethylformamide (13 ml)
  5. additionThe reaction mixture was added a water
  6. filtrationthe isolated precipitate was collected by filtration

出典と根拠

ORDレコード
ord-461247dde3d042289adb42e5382bacb8
出典データセット
uspto-grants-1994_11
特許番号
US05364871

反応ノート

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