Hydrochloric Acid → 4-Chloro-2'-nitrobutyrophenone

HRID 2380076ノート

反応式

HRID 2380076 の反応式
[N+:1]([C:4]1[CH:17]=[CH:16][CH:15]=[CH:14][C:5]=1[C:6]([CH:8]1[CH:12]=[CH:11]OC1=O)=[O:7])([O-:3])=[O:2].[ClH:18]>>[Cl:18][CH2:11][CH2:12][CH2:8][C:6]([C:5]1[CH:14]=[CH:15][CH:16]=[CH:17][C:4]=1[N+:1]([O-:3])=[O:2])=[O:7]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 15766854o-nitrobenzoyl-2(3H)-furanone

生成物 1

HCID 118064124-Chloro-2'-nitrobutyrophenone収率 95%

反応条件

温度
70 °C

実験手順

A mixture of dihydro-3-(o-nitrobenzoyl-2(3H)-furanone (2.0 g, 8.5 mmole) in 10 g of 37% HCl solution is stirred at 70° C. until reaction is complete by TLC, cooled to room temperature and extracted with toluene. The organic extracts are combined and concentrated in vacuo to give the title product as a golden oil, 1.84 g (95% yield), 99% pure by HPLC analysis, identified by 1HNMR.

後処理

  1. temperaturecooled to room temperature
  2. extractionextracted with toluene
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-88200e3d98524546b929cc420a52eb75
出典データセット
uspto-grants-1994_11
特許番号
US05364968

反応ノート

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