3-Hydroxybutyric Acid → Decyl 3-hydroxybutanoate

HRID 2380181ノート

反応式

HRID 2380181 の反応式
[OH:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].[CH2:8](O)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]>S(=O)(=O)(O)O>[OH:1][CH:2]([CH3:7])[CH2:3][C:4]([O:6][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[O:5]

参加物

4

反応物 2

HCID 4413-Hydroxybutyric AcidHCID 81741-Decanol

生成物 1

HCID 18955013Decyl 3-hydroxybutanoate収率 58%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

反応条件

温度
140 °C

実験手順

A 100 ml of one neck round bottom flask equipped with a Dean Start trap, condensor and nitrogen inlet/outlet was charged with 20.8 g (0.20 moles) 3-hydroxybutyric acid, 63.3 g (0.40 moles) decyl alcohol, and 0.1 g sulfuric acid. The mixture was heated to 140° C. for 8 hours and water was collected as the reaction proceeded. The acid was neutralized by washing three times with 50 ml saturated sodium bicarbonate solution. The organic layer was collected and dried over magnesium sulfate. Excess decyl alcohol was removed by high vacuum distillation to yield 28.3 g (58% yield) of clear viscous colorless oil. According to GC the product is 89.4% pure.

後処理

  1. customwater was collected as the reaction
  2. washby washing three times with 50 ml saturated sodium bicarbonate solution
  3. customThe organic layer was collected
  4. dry with materialdried over magnesium sulfate
  5. customExcess decyl alcohol was removed by high vacuum distillation

出典と根拠

ORDレコード
ord-3c81ed740adb432a8f2065d89c7cabaa
出典データセット
uspto-grants-1994_11
特許番号
US05366665

反応ノート

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