関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl butyrate | HCID 12180 | — |
| 反応物 | 4,6-Diphenyl-2-pyridone | HCID 3846201 | — |
| 反応物 | Methyl 6-bromo-2-ethylhexanoate | HCID 18987246 | — |
| 触媒 | HCID 178418647 | HCID 178418647 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl 2-ethyl-6-[(4,6-diphenyl-2-pyridyl)oxy]hexanoate | HCID 18987170 | — |
反応手順
The procedure in Example 5 is followed but using 4,6-diphenyl-2-pyridinone (2.8 g) (prepared by analogy with the method described in Patent EP 108 592 from methyl butanoate), methyl 6-bromo-2-ethylhexanoate (5.4 g), silver carbonate (1.6 g) and dimethylformamide (100 cc). The reaction mixture is heated at 100° C. for 31 hours then at 120° C. for 40 hours. The product is purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 9-1). (yellow oil)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05366982 |
|---|
| 出典データセット | uspto-grants-1994_11 |
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| ORD ID | ord-876ac8bc29ed4b1ba525258cdde6c048 |
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| 出典メモ | uspto-grants-1994_11 |
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