Water → 1-(3-Methylbutyl)-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine

HRID 238057

反応式

HRID 238057 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]1[C:19]2[C:14](=[N:15][CH:16]=[N:17][C:18]=2[NH2:20])[NH:13][N:12]=1.[C:21]([O-])([O-])=O.[K+].[K+].[CH2:27](Br)[CH:28]([CH3:30])[CH3:29].O>CN(C=O)C>[CH2:21]([N:13]1[C:14]2=[N:15][CH:16]=[N:17][C:18]([NH2:20])=[C:19]2[C:11]([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)=[N:12]1)[CH2:27][CH:28]([CH3:30])[CH3:29]

参加物

6

反応物 4

HCID 962WaterHCID 65551-Bromo-2-methylpropaneHCID 11430Potassium CarbonateHCID 178508705HCID 178508705、化合物

生成物 1

HCID 529432581-(3-Methylbutyl)-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (50 mg, 0.21 mmol) was dissolved in DMF (1.5 mL) and K2CO3 (110 mg, 0.8 mmol) and isobutyl bromide were added. The reaction was heated to 60° C. overnight, then cooled to RT and poured into water (30 mL). The precipitate was collected by filtration. ESI-MS (M+H)+ m/z calcd 332.2, found 332.3.

後処理

  1. temperaturecooled to RT
  2. filtrationThe precipitate was collected by filtration

出典と根拠

ORDレコード
ord-d44d2eb8810545989474eba8845bad27
出典データセット
uspto-grants-2014_02
特許番号
US08642604B2

関連ノート

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