化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 7-Benzyloxy-4-(2-fluoro-4-methylanilino)-6-methoxyquinazoline hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | 2-Fluoro-4-methylaniline | HCID 67984 | — |
| 反応物 | tert-Butyl 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylate | HCID 11049999 | — |
| 生成物 | 7-Benzyloxy-4-(2-fluoro-4-methylanilino)-6-methoxyquinazoline hydrochloride | HCID 17973220 | 91% |
反応手順
Using an analogous procedure to that described in Example 6, 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (1.55 g, 5.15 mmol), (prepared, for example, as described in WO 97/22596, Example 1), was reacted with 2-fluoro-4-methylaniline (700 mg, 5.67 mmol) in isopropanol (90 ml) containing 6.2M hydrogen chloride in isopropanol (80 μl, 0.51 mmol) to give 7-benzyloxy-4-(2-fluoro-4-methylanilino)-6-methoxyquinazoline hydrochloride (2 g, 91%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642608B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-92dd6146bcee41eca7755054989ab599 |
| 出典メモ | uspto-grants-2014_02 |