4-Chlorophenylglyoxylic acid → 2-(4-chlorophenyl)-4-cyclopropylmethylpyrido[2,3-b]pyrazin-3(4H)-one

HRID 238125

反応式

HRID 238125 の反応式
[CH:1]1([CH2:4][NH:5][C:6]2[C:11]([NH2:12])=[CH:10][CH:9]=[CH:8][N:7]=2)[CH2:3][CH2:2]1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=O)[C:21](O)=[O:22])=[CH:16][CH:15]=1>CO>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[C:21](=[O:22])[N:5]([CH2:4][CH:1]3[CH2:2][CH2:3]3)[C:6]3[N:7]=[CH:8][CH:9]=[CH:10][C:11]=3[N:12]=2)=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 1459984-Chlorophenylglyoxylic acidHCID 28902457N2-(cyclopropylmethyl)pyridine-2,3-diamine

生成物 1

HCID 442184372-(4-chlorophenyl)-4-cyclopropylmethylpyrido[2,3-b]pyrazin-3(4H)-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

430 mg (2.63 mM) of N2-(cyclopropylmethyl)pyridine-2,3-diamine and 485.4 mg (2.63 mM) of (4-chlorophenyl)(oxo)acetic acid in 6 ml of methanol were refluxed for 16 h. A solid crystallized. The compound was filtered and washed with methanol to give

後処理

  1. customA solid crystallized
  2. filtrationThe compound was filtered
  3. washwashed with methanol
  4. customto give

出典と根拠

ORDレコード
ord-f13aca96aa2344e19f3ce41471f785d1
出典データセット
uspto-grants-2014_02
特許番号
US08642617B2

関連ノート

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