Nitromethane → HCID 68553487、化合物
反応式
[CH3:1][O:2][C:3]1[C:11](OC)=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5]([CH:14]=O)=[CH:6][NH:7]2.[C:16]([O-:19])(=O)C.[NH4+].[N+:21]([CH3:24])([O-:23])=[O:22]>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5]([CH:14]=[CH:24][N+:21]([O-:23])=[O:22])=[C:6]([O:19][CH3:16])[NH:7]2参加物
4
実験手順
A solution of 4,5-dimethoxyindole-3-carbaldehyde (0.21 g, 1.02 mmol) and ammonium acetate (0.1268 g, 1.60 mmol) in nitromethane (10 cm3) was stirred at 70-75° C. under nitrogen for 11 hours using the method of Macor et al. The mixture was concentrated under vacuum and partitioned between water and ethyl acetate. The organic layer was washed with brine, dried with MgS04, and evaporated under vacuum to afford dimethoxy-3-(2-nitroethenyl)indole (0.25 g, 99%) as a brown solid.
後処理
- concentrationwas concentrated under vacuum