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5-Bromo-2,4-dichloropyrimidine → 5-Bromo-2-chloro-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Bromo-2,4-dichloropyrimidine | HCID 289973 | — |
| 反応物 | 4-Aminotetrahydropyran | HCID 419223 | — |
| 生成物 | 5-Bromo-2-chloro-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine | HCID 59550890 | 83% |
反応手順
In the reaction of 5-bromo-2,4-dichloropyrimidine (300 mg, 1.32 mmol) with tetrahydropyran-4-ylamine (144 mg, 1.42 mmol) according to GP 2, the desired product is obtained in 83% yield (320 mg) after chromatographic purification (silica gel, ethyl acetate/hexane with ethyl acetate: 0-100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642611B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-7f2110dc64784d70b398661d02afffe8 |
| 出典メモ | uspto-grants-2014_02 |