Trimethylsilylacetylene → 5-Trimethylsilanylethynyl-1H-indazole

反応式

I[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.[CH3:11][Si:12]([C:15]#[CH:16])([CH3:14])[CH3:13]>>[CH3:11][Si:12]([C:15]#[C:16][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2)([CH3:14])[CH3:13]

参加物

反応物 2

HCID 66111Trimethylsilylacetylene

HCID 218947395-Iodo-1H-indazole

生成物 1

HCID 579507415-Trimethylsilanylethynyl-1H-indazole収率 46%

実験手順

In an adaption of GP 8a, 5-Iodo-1H-indazole (0.98 g, 4.02 mmol) was reacted with trimethylsilyl acetylene (0.60 mL, 4.22 mmol) at 90° C. for 5 h to give 395 mg (46%) of pure 5-(trimethylsilyl)ethynyl-1H-indazole.

出典と根拠

ORDレコード: ord-d97e33d95d5b435aabfb6172bc657155
出典データセット: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08642611B2

反応ノート

読み込み中…