Dimethyl phenylphosphonite → (3,5-Di-tert-butyl-4-hydroxy-benzyl)-phenyl-phosphinic acid methyl ester

HRID 2381876

反応式

HRID 2381876 の反応式
C[O:2][P:3]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[O:4][CH3:5].[C:12]([C:16]1[CH:17]=[C:18]([CH:21]=[C:22]([C:25]([CH3:28])([CH3:27])[CH3:26])[C:23]=1[OH:24])[CH2:19]Cl)([CH3:15])([CH3:14])[CH3:13]>>[CH3:5][O:4][P:3]([CH2:19][C:18]1[CH:17]=[C:16]([C:12]([CH3:13])([CH3:15])[CH3:14])[C:23]([OH:24])=[C:22]([C:25]([CH3:28])([CH3:27])[CH3:26])[CH:21]=1)([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:2]

参加物

3

反応物 2

HCID 76277Dimethyl phenylphosphoniteHCID 123786012,6-Di-tert-butyl-4-(chloromethyl)phenol

生成物 1

HCID 57909093(3,5-Di-tert-butyl-4-hydroxy-benzyl)-phenyl-phosphinic acid methyl ester収率 83%

反応条件

温度
110 °C

実験手順

A mixture of 5 grams (29 mmol) of dimethylphenylphosphonite with 7.5 grams (29 mmol) of 3,5-di-tert-butyl-4-hydroxybenzyl chloride (CAS REG #955-01-1) is heated at 110° C. for 1 hour and cooled to obtain a white solid. The resultant solid is crystallized from 100 mL of hexane to give 9 grams (83% yield) of (3,5-di-tert-butyl-4-hydroxy-benzyl)-phenyl-phosphinic acid methyl ester as a white solid mp 112-114° C.

後処理

  1. temperaturecooled
  2. customto obtain a white solid
  3. customThe resultant solid is crystallized from 100 mL of hexane

出典と根拠

ORDレコード
ord-d69dcbc6ba1048338ea803bf42e88474
出典データセット
uspto-grants-2012_09
特許番号
US08258253B2

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