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Pyrrolo[3,2-b]pyridin-1-ylamine → 4-Methyl-2-pyridin-3-yl-pyrimidine-5-carboxylic acid (5-fluoro-indol-1-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrrolo[3,2-b]pyridin-1-ylamine | HCID 19601545 | — |
| 反応物 | 4-Methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid (5-fluoro-indol-1-yl)-amide | HCID 59199952 | — |
| 反応物 | 4-Methyl-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid | HCID 61702025 | — |
| 生成物 | 4-Methyl-2-pyridin-3-yl-pyrimidine-5-carboxylic acid (5-fluoro-indol-1-yl)-amide | HCID 59200069 | — |
反応手順
Following procedures similar to those of Example 127 but substituting 4-methyl-2-pyridin-3-yl-pyrimidine-5-carboxylic acid for 4-methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid, and substituting 5-fluoro-indol-1-ylamine for pyrrolo[3,2-b]pyridine-1-ylamine, there is prepared 4-methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid (5-fluoro-indol-1-yl)-amide (34%) as a solid. MS: 348 (M+H); 1H NMR (300 MHz, CD3OD): δ 2.85 (s, 3H), 6.57 (m, H), 7.02 (m, H), 7.23-7.46 (m, 2H), 7.62 (m, H), 8.70 (d, H), 8.91 (d, H), 9.17 (s, H), 9.63 (s, H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08258130B2 |
| 出典データセット | uspto-grants-2012_09 |
| ORD ID | ord-77a416d1fc9247239a0f9e2f3f6c9015 |
| 出典メモ | uspto-grants-2012_09 |