Methylamine → HCID 10316869、化合物

HRID 2382225ノート

反応式

HRID 2382225 の反応式
Cl[CH2:2][CH2:3][C@@H:4]([O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[I:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:19][NH2:20]>C(O)C>[CH3:19][NH:20][CH2:2][CH2:3][C@@H:4]([O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[I:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 10248728HCID 10248728、化合物

生成物 1

HCID 10316869HCID 10316869、化合物収率 97.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Compound 1-A (2.68 g, 7.2 mmole) was dissolved in an aqueous solution of ethanol (80 ml) and methylamine (160 ml), and heated to reflux for 30 h. After cooling, the solution was extracted with chloroform (100 ml, twice), and an organic layer was decanted. The organic layer was dried over anhydrous sodium sulfate, and dried by evaporation under vacuum, to obtain the product as oil (2.75 g, 97.4%).

後処理

  1. temperatureheated
  2. temperatureto reflux for 30 h
  3. temperatureAfter cooling
  4. extractionthe solution was extracted with chloroform (100 ml
  5. customtwice), and an organic layer was decanted
  6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  7. customdried by evaporation under vacuum

出典と根拠

ORDレコード
ord-9ea7b392a9ea418592cc53c4356f519e
出典データセット
uspto-grants-2012_09
特許番号
US08258331B2

反応ノート

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