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Pyridine → 3-Propionylamino-pyrazine-2-carboxylic acid amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 3-Amino-2-pyrazinecarboxylic acid | HCID 72656 | — |
| 反応物 | Azane;hydrate | HCID 12896473 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Propionic anhydride | HCID 31263 | — |
| 生成物 | 3-Propionylamino-pyrazine-2-carboxylic acid amide | HCID 59993513 | 43% |
反応手順
A mixture of 3-amino-pyrazine-2-carboxylic acid (20.9 g, 0.15 mol), pyridine (29.6 g, 0.375 mol) and DMAP (1.83 g, 15 mmol) in propionic acid anhydride (100 mL) was stirred at room temperature overnight. The reaction mixture was poured into NH3.H2O (500 mL) partially at 0° C. After stirred for 30 min at 0° C., the precipitated solid was filtered, washed with water, dried in air to give 3-propionylamino-pyrazine-2-carboxylic acid amide as a beige solid (12.4 g, 43%), which was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642609B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-e462de6e1306463e8024cdb00ecdc717 |
| 出典メモ | uspto-grants-2014_02 |