1-Boc-4-(2,4-difluorophenyl)-4-hydroxypiperidine → 4-(2,4-Difluorophenyl)piperidin-4-ol
反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[F:22][C:16]1[CH:17]=[C:18]([F:21])[CH:19]=[CH:20][C:15]=1[C:11]1([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1参加物
4
実験手順
4-(2,4-Difluoro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (0.2 g) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 1 mL). The mixture was stirred for 1 hour and the solvent removed by evaporation under vacuum. The solid was triturated from ether to afford the title compound as a pale yellow solid (0.08 g). LCMS m/z 214.25 [M+H]+. R.T.=1.06 min (Analytical Method 4).
後処理
- customthe solvent removed by evaporation under vacuum
- customThe solid was triturated from ether
出典と根拠
- ORDレコード
- ord-4c9254c4baa64e74a08e4e97444eb447
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642621B2
反応ノート
読み込み中…