4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)pyrimidin-2-amine → Pyridine-3-sulfonic acid [5-(2-amino-4-methyl-pyrimidin-5-yl)-2-chlorophenyl]-amide
反応式
[CH3:1][C:2]1[C:7](B2OC(C)(C)C(C)(C)O2)=[CH:6][N:5]=[C:4]([NH2:17])[N:3]=1.Br[C:19]1[CH:20]=[CH:21][C:22]([Cl:35])=[C:23]([NH:25][S:26]([C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)(=[O:28])=[O:27])[CH:24]=1>>[NH2:17][C:4]1[N:3]=[C:2]([CH3:1])[C:7]([C:19]2[CH:20]=[CH:21][C:22]([Cl:35])=[C:23]([NH:25][S:26]([C:29]3[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=3)(=[O:28])=[O:27])[CH:24]=2)=[CH:6][N:5]=1参加物
3
実験手順
This compound is prepared as described for Example 3-25 (step 2) from 4-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl]-pyrimidin-2-ylamine (Intermediate G) and pyridine-3-sulfonic acid [5-bromo-2-chloro-phenyl]-amide.
後処理
- customThis compound is prepared