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6-Morpholinonicotinoyl Chloride → N-[5-(cyclohexylamino)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-6-morpholin-4-ylnicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Morpholinonicotinoyl Chloride | HCID 2776461 | — |
| 反応物 | N5-cyclohexyl[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine | HCID 25216186 | — |
| 生成物 | N-[5-(cyclohexylamino)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-6-morpholin-4-ylnicotinamide | HCID 59437487 | — |
反応手順
The title compound was prepared following procedure described for intermediate B1, but starting from N5-cyclohexyl[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine ((A9), 174 mg; 0.75 mmol; 1.0 eq.) and 6-morpholinonicotinoyl chloride (255 mg; 1.12 mmol; 1.5 eq.) as a white solid (15 mg, 5%). HPLC, Rt: 2.83 min. (purity 99.0%). LC/MS, M+(ESI): 422.2, M−(ESI): 420.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08263595B2 |
| 出典データセット | uspto-grants-2012_09 |
| ORD ID | ord-0c6dbc99625f4589afc87b0796503f30 |
| 出典メモ | uspto-grants-2012_09 |