Triethylamine → 5-(3-Chloroprop-1-EN-1-YL)-2-(4-fluorophenyl)pyridine
反応式
CS([Cl:5])(=O)=O.[F:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:18]=[CH:17][C:16]([CH:19]=[CH:20][CH2:21]O)=[CH:15][CH:14]=2)=[CH:9][CH:8]=1.C(N(CC)CC)C>ClCCl>[Cl:5][CH2:21][CH:20]=[CH:19][C:16]1[CH:15]=[CH:14][C:13]([C:10]2[CH:11]=[CH:12][C:7]([F:6])=[CH:8][CH:9]=2)=[N:18][CH:17]=1参加物
5
実験手順
436 mg (3.8 mmol) of methanesulfonyl chloride were slowly added at room temperature to 513 mg (2.24 mmol) of 3-(6-(4-fluorophenyl)pyridin-3-yl)prop-2-en-1-ol and 679 mg (6.71 mmol) of triethylamine in 20 ml of dichloromethane. The mixture was stirred at room temperature for 6 h and extracted with a sodium hydrogencarbonate solution. The organic phase was evaporated to yield 550 mg of the title compound. MS: M+H+=248.1.
後処理
- extractionextracted with a sodium hydrogencarbonate solution
- customThe organic phase was evaporated
出典と根拠
- ORDレコード
- ord-8d5d00b21e0943be82c2cad4c83c6aea
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642620B2
反応ノート
読み込み中…