1-Bromo-3-chlorobenzene → 1-(3-Chloro-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

関与物質

役割	名称	HCID	仕込み量
反応物	1-Bromo-3-chlorobenzene	HCID 7928	—
反応物	1,2-Diaminocyclohexane, trans-	HCID 43806	—
反応物	Potassium Phosphate, Tribasic	HCID 62657	—
反応物	1-(4-Methylpyridin-3-yl)imidazolidin-2-one	HCID 59636170	—
触媒	Copper iodide	HCID 83717	—
溶媒	1,4-Dioxane	HCID 31275	—
生成物	1-(3-Chloro-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one	HCID 49872153	59.25%

反応手順

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 200 mg, 1.129 mmol) was reacted with 1-bromo-3-chloro-benzene (0.281 g, 1.471 mmol), 1,4-dioxane (20 mL), copper iodide (0.021 g, 0.110 mmol), trans-1,2-diamino cyclohexane (0.038 g, 0.333 mmol) and potassium phosphate (0.718 g, 3.386 mmol) to afford 192 mg of the product (59.25% yield).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08263635B2
出典データセット	uspto-grants-2012_09
ORD ID	ord-6bde5cf2b0254d2483c44857c4443322
出典メモ	uspto-grants-2012_09