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Ethyl Acetate → 1-(Benzothiazol-6-ylamino)-butan-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 1-Bromo-2-butanone | HCID 13156 | — |
| 反応物 | 6-Aminobenzothiazole | HCID 68288 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 1-(Benzothiazol-6-ylamino)-butan-2-one | HCID 59636195 | 34.1% |
反応手順
Sodium acetate (300 mg, 3.66 mmol) and 1-bromo-butan-2-one (0.373 mL, 3.66 mmol) were added to a stirred solution of benzothiazol-6-ylamine (500 mg, 3.328 mmol) in methanol (10 mL) under nitrogen atmosphere. The resulting reaction mass was stirred at room temperature for 24 hours. The reaction was monitored by TLC (20% ethyl acetate in hexane). The reaction mixture was filtered and the solid collected was dried under reduced pressure to afford 250 mg of the product (32% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08263635B2 |
| 出典データセット | uspto-grants-2012_09 |
| ORD ID | ord-7adb840d11424fd2a79c0e22e8c79c41 |
| 出典メモ | uspto-grants-2012_09 |