Sodium Cyanide → 3-(Cyanomethyl)benzoic acid
反応式
Br[CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=[O:7].[C-:12]#[N:13].[Na+]>CO>[C:12]([CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=[O:7])#[N:13]参加物
4
反応条件
- 温度
- 70 °C
実験手順
To a solution of 3-bromomethylbenzoic acid (2.29 g, 10 mmol) in methanol (30 mL) is added sodium cyanide (0.49 g, 10 mmol) and the mixture is stirred at 70° C. for 2 hrs. The solvent is removed under reduced pressure and water is added to the residue. The mixture is extracted with ether and the organic phase is dried over sodium sulfate. The solvent is removed under reduced pressure and the residue purified by column chromatography using CH2Cl2 as eluent to give 3-cyanomethylbenzoic acid.
後処理
- customThe solvent is removed under reduced pressure and water
- additionis added to the residue
- extractionThe mixture is extracted with ether
- dry with materialthe organic phase is dried over sodium sulfate
- customThe solvent is removed under reduced pressure
- customthe residue purified by column chromatography
出典と根拠
- ORDレコード
- ord-4ef984e7f6424b388fcec863111b9a63
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08263629B2
反応ノート
読み込み中…