Water → N-[3-bromo-5-(trifluoromethyl)phenyl]acetamide

HRID 238427

反応式

HRID 238427 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([NH2:12])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH3:13][C:14](OC(C)=O)=[O:15].O>CC(O)=O>[Br:1][C:2]1[CH:3]=[C:4]([NH:12][C:14](=[O:15])[CH3:13])[CH:5]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 27358803-Bromo-5-(trifluoromethyl)aniline

生成物 1

HCID 21959349N-[3-bromo-5-(trifluoromethyl)phenyl]acetamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

3-Bromo-5-(trifluoromethyl)phenylamine (5 g, Alfa-Aesar) was dissolved in AcOH (140 ml) and Ac2O (5.9 ml, Aldrich) was added. The reaction was stirred at RT overnight. The mixture was added slowly to H2O (˜700 ml) forming a white precipitate. The solid was isolated by filtration, washed with H2O and dried under vacuum to yield N-(3-bromo-5-trifluoromethyl-phenyl)-acetamide.

後処理

  1. customforming a white precipitate
  2. customThe solid was isolated by filtration
  3. washwashed with H2O
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-d362e81504494fc290da42d0f1a2643c
出典データセット
uspto-grants-2014_02
特許番号
US08642624B2

関連ノート

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