Benzenamine, 3,5-bis(trifluoromethyl)- → N-[3,5-bis(trifluoromethyl)phenyl]-5-fluoro-2-hydroxy-benzamide

反応式

[F:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]([F:26])([F:25])[C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[NH2:17]>>[F:12][C:13]([F:25])([F:26])[C:14]1[CH:15]=[C:16]([NH:17][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=2[OH:11])[CH:18]=[C:19]([C:21]([F:22])([F:24])[F:23])[CH:20]=1

参加物

反応物 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-

HCID 676585-Fluorosalicylic acid

生成物 1

HCID 10067510N-[3,5-bis(trifluoromethyl)phenyl]-5-fluoro-2-hydroxy-benzamide収率 58.7%

実験手順

Using 5-fluorosalicylic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

出典と根拠

ORDレコード: ord-c23775a1af994b3c8db3cbdd2604c2e0
出典データセット: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08263657B2

反応ノート

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