5-Bromosalicylic acid → 5-Bromo-N [3-bromo-5-(trifluoromethyl)phenyl]-2-hydroxybenzamide

反応式

[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[Br:12][C:13]1[CH:14]=[C:15]([CH:17]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:19]=1)[NH2:16]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:16][C:15]1[CH:17]=[C:18]([C:20]([F:21])([F:22])[F:23])[CH:19]=[C:13]([Br:12])[CH:14]=1)=[O:9]

参加物

反応物 2

HCID 69725-Bromosalicylic acid

HCID 27358803-Bromo-5-(trifluoromethyl)aniline

生成物 1

HCID 178602635-Bromo-N [3-bromo-5-(trifluoromethyl)phenyl]-2-hydroxybenzamide収率 73.3%

実験手順

Using 5-bromosalicylic acid and 3-bromo-5-(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

出典と根拠

ORDレコード: ord-09da93bd55dd4e09b2f0071d3bb6340f
出典データセット: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08263657B2

反応ノート

読み込み中…