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5-Aminopentan-1-ol → N-(5-hydroxypentyl)-3-(N-vinylformamido)propionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Aminopentan-1-ol | HCID 75634 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 反応物 | methyl 3-(N-vinylformamido)propionate | HCID 10964771 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-(5-hydroxypentyl)-3-(N-vinylformamido)propionamide | HCID 19690346 | — |
反応手順
The apparatus of Example 2 was charged with 15.7 grams (0.1 mol) of methyl 3-(N-vinylformamido)propionate, 10.3 grams (0.1 mol) of 5-amino-1-pentanol and 0.12 gram of 25% sodium methoxide in methanol solution. The mixture was stirred at 90° C. for 3 hours after which the methanol coproduct was removed by distillation at reduced pressure. NMR analysis of the remaining amber liquid indicated about 69% conversion to the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728878 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-575fdaab9b024e09a2ac34fb099e5fd0 |
| 出典メモ | uspto-grants-1998_03 |