Hydrochloric Acid → 3,3-Dimethyl-6-nitroindoline
反応式
[CH3:1][C:2]1([CH3:17])[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=2)[N:4](C(=O)C)[CH2:3]1.Cl>CCO>[CH3:1][C:2]1([CH3:17])[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=2)[NH:4][CH2:3]1参加物
4
反応条件
- 温度
- 70 °C
実験手順
1-(3,3-Dimethyl-6-nitro-2,3-dihydro-indol-1-yl)ethanone (1.8 g, Step C) was dissolved in EtOH (50 mL), 12N HCl (50 mL) was added and the resulting mixture was heated at 70° C. overnight. After the mixture was concentrated in vacuo, it was partitioned between saturated NaHCO3 solution and EtOAc, the resulting organic layer was dried over MgSO4, filtered and concentrated in vacuo to afford a yellow solid. MS: 193 (M+1). Calc'd. for C10H12N2O2—192.21.
後処理
- concentrationAfter the mixture was concentrated in vacuo, it
- customwas partitioned between saturated NaHCO3 solution and EtOAc
- dry with materialthe resulting organic layer was dried over MgSO4
- filtrationfiltered
- concentrationconcentrated in vacuo
- customto afford a yellow solid
出典と根拠
- ORDレコード
- ord-fb5c69e5fa60499cb5685b37998bf572
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642624B2
反応ノート
読み込み中…