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1-Fluoro-4-(methylsulphonyl)benzene → [6-Chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Fluoro-4-(methylsulphonyl)benzene | HCID 67994 | — |
| 反応物 | (6-Chloro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester | HCID 59326538 | — |
| 反応物 | 2-(4-Fluoro-benzylidene)-succinic acid 1-methyl ester | HCID 67303799 | — |
| 生成物 | [6-Chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester | HCID 59326613 | 33.4% |
反応手順
Starting with (6-chloro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester (132 mg, 0.5 mmol) and 1-fluoro-4-methanesulfonyl-benzene (174 mg, 1.0 mmol), using a method analogous to the one described for the methyl ester of example 1-1, [6-chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (70 mg, 33%) was obtained as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642629B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-a59767866add42b69dd7390a8d6045d1 |
| 出典メモ | uspto-grants-2014_02 |