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2-Bromo-5-(ethylsulfonyl)pyridine → [4-(5-Ethanesulfonyl-pyridin-2-yloxy)-6-fluoro-1-methyl-naphthalen-2-yl]-acetic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-5-(ethylsulfonyl)pyridine | HCID 53393184 | — |
| 反応物 | (6-Fluoro-4-hydroxy-1-methyl-naphthalen-2-yl)acetic acid methyl ester | HCID 59326584 | — |
| 反応物 | 2-(4-Fluoro-benzylidene)-succinic acid 1-methyl ester | HCID 67303799 | — |
| 生成物 | [4-(5-Ethanesulfonyl-pyridin-2-yloxy)-6-fluoro-1-methyl-naphthalen-2-yl]-acetic acid methyl ester | HCID 59326521 | 75% |
反応手順
Starting with (6-fluoro-4-hydroxy-1-methyl-naphthalen-2-yl)acetic acid methyl ester (18 mg, 0.073 mmol) and 2-bromo-5-ethanesulfonyl-pyridine (27 mg, 0.109 mmol), using a method analogous to the one described for the methyl ester of example 1-1, [4-(5-ethanesulfonyl-pyridin-2-yloxy)-6-fluoro-1-methyl-naphthalen-2-yl]-acetic acid methyl ester (22.7 mg, 75%) was obtained as a light yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642629B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-c465bafad2a345ea88c1e1c36d5c4835 |
| 出典メモ | uspto-grants-2014_02 |