Methanesulfonyl chloride → N-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-N-(2-pyridin-4-yl-ethyl)-methanesulfonamide

反応式

[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:21]=[CH:22][CH:23]=2)[CH2:11][NH:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[CH:5]=[CH:4][N:3]=1.[CH3:24][S:25](Cl)(=[O:27])=[O:26]>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:21]=[CH:22][CH:23]=2)[CH2:11][N:12]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[S:25]([CH3:24])(=[O:27])=[O:26])[CH:5]=[CH:4][N:3]=1

参加物

反応物 2

HCID 31297Methanesulfonyl chloride

HCID 86603257N-(3-(2-chloropyrimidin-4-yl)benzyl)-2-(pyridine-4-yl)ethanamine

生成物 1

HCID 86603258N-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-N-(2-pyridin-4-yl-ethyl)-methanesulfonamide

実験手順

Intermediate 20 was coupled with methanesulfonyl chloride following procedure D. LC-MS showed the product had the expected M+H+ of 403.

出典と根拠

ORDレコード: ord-0cacbf1432474dcda4b718c465993ca6
出典データセット: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08268822B2

反応ノート

読み込み中…