化工社化工社 化学情報印刷レポート · 研究参考用
Trimethyl orthoformate → 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethyl orthoformate | HCID 9005 | — |
| 反応物 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 反応物 | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | — |
| 生成物 | 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine | HCID 86603261 | — |
反応手順
Intermediate 1 (3.69 g) was refluxed for two hours in trimethylorthoformate containing 10 mL of 4N HCl/dioxane. The solvent was removed by rotary evaporation to give product, which showed the expected M+H+ of 265 by LC-MS.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08268822B2 |
| 出典データセット | uspto-grants-2012_09 |
| ORD ID | ord-84ca9525207540389837a37219b4733d |
| 出典メモ | uspto-grants-2012_09 |