4-Amino-1-Boc-piperidine → 4-[5-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzylamino]-piperidine-1-carboxylic acid tert-butyl ester

HRID 2386471

反応式

HRID 2386471 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([F:16])=[C:12]([CH:15]=2)[CH:13]=O)[CH:5]=[CH:4][N:3]=1.[C:17]([O:21][C:22]([N:24]1[CH2:29][CH2:28][CH:27]([NH2:30])[CH2:26][CH2:25]1)=[O:23])([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22]([N:24]1[CH2:29][CH2:28][CH:27]([NH:30][CH2:13][C:12]2[CH:15]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:9]=[CH:10][C:11]=2[F:16])[CH2:26][CH2:25]1)=[O:23])([CH3:20])([CH3:18])[CH3:19]

参加物

3

反応物 2

HCID 12682914-Amino-1-Boc-piperidineHCID 249019815-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzaldehyde

生成物 1

HCID 866032934-[5-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzylamino]-piperidine-1-carboxylic acid tert-butyl ester

実験手順

Intermediate 89 was coupled with 4-Amino-piperidine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product was >95% pure and had the expected M+H+ of 421.

出典と根拠

ORDレコード
ord-b45e670e9a9147ca9e6b8859f356cb87
出典データセット
uspto-grants-2012_09
特許番号
US08268822B2

関連ノート

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