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Methyl Acetate → [4-(3-Bromo-5-ethanesulfonyl-pyridin-2-yloxy)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Acetate | HCID 6584 | — |
| 反応物 | 3-Bromo-2-chloro-5-(ethylsulfonyl)pyridine | HCID 59326565 | — |
| 反応物 | 2-(4-Fluoro-benzylidene)-3-methyl-succinic acid 1-methyl ester | HCID 66775587 | — |
| 生成物 | [4-(3-Bromo-5-ethanesulfonyl-pyridin-2-yloxy)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester | HCID 59326492 | 73.9% |
反応手順
Starting with 6-fluoro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester (124 mg, 0.50 mmol) and 3-bromo-2-chloro-5-ethanesulfonyl-pyridine (157 mg, 0.55 mmol), using a method analogous to the one described for the methyl ester of example 2-1, [4-(3-bromo-5-ethanesulfonyl-pyridin-2-yloxy)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (183 mg, 73.9%) was obtained as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642629B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-1794439bd43c4443a22a56ee45e8677f |
| 出典メモ | uspto-grants-2014_02 |