反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([C:11]1[CH:12]=[CH:13][C:14]([O:20][CH3:21])=[C:15](B(O)O)[CH:16]=1)=[O:10]>>[Cl:1][C:2]1[N:7]=[C:6]([C:13]2[CH:12]=[C:11]([CH:16]=[CH:15][C:14]=2[O:20][CH3:21])[CH:9]=[O:10])[CH:5]=[CH:4][N:3]=1参加物
3
実験手順
2,4 dichloropyrimidine and 5-formyl-2-methoxyphenylboronic acid was coupled following procedure A. The yield was 70%. LC-MS showed the product was >95% pure and had the expected M+H+ of 249. 1H NMR (Varian 300 MHz, MeOD-d6, shifts relative to the solvent peak at 3.33 ppm) δ 9.9 (s, 1H) 8.7 (d, 1H) 8.4 (s, 1H) 8.0 (d, 2H) 7.4 (d, 1H) 3.9 (s, 3H).
出典と根拠
- ORDレコード
- ord-b40de3aebce94360b7f3158ef094e7e1
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08268822B2
関連ノート
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