4-chloro-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine → N4-{2-[(2-aminopyrimidin-4-yl)amino]ethyl}-N4-methyl-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidine-2,4-diamine
反応式
Cl.Cl.[CH3:3][NH:4][CH2:5][CH2:6][NH:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([NH2:14])[N:9]=1.Cl[C:16]1[C:17]2[CH2:27][CH2:26][CH2:25][C:24]3[CH:28]=[CH:29][CH:30]=[CH:31][C:23]=3[C:18]=2[N:19]=[C:20]([NH2:22])[N:21]=1>>[NH2:14][C:10]1[N:9]=[C:8]([NH:7][CH2:6][CH2:5][N:4]([CH3:3])[C:16]2[C:17]3[CH2:27][CH2:26][CH2:25][C:24]4[CH:28]=[CH:29][CH:30]=[CH:31][C:23]=4[C:18]=3[N:19]=[C:20]([NH2:22])[N:21]=2)[CH:13]=[CH:12][N:11]=1参加物
3
実験手順
The product from Example 2A (95 mg, 0.237 mmol) and the product from Example 1C (50 mg, 0.203 mmol) were combined under the conditions described in Example 1F to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.62-7.67 (m, 1H) 7.58 (d, J=5.43 Hz, 1H) 7.28-7.37 (m, 2H) 7.23-7.28 (m, 1H) 6.89 (s, 1H) 5.94 (s, 2H) 5.82 (s, 2H) 5.70 (d, J=5.76 Hz, 1H) 3.43-3.55 (m, 4H) 2.99-3.04 (m, 3H) 2.50-2.58 (m, 2H) 2.15 (dd, J=16.11, 5.93 Hz, 4H); MS (ESI+) m/z 377.0 (M+H)+.