tert-Butyl (3-aminopropyl)carbamate → tert-butyl 3-[(2-amino-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-4-yl)amino]propylcarbamate

HRID 2386981ノート

反応式

HRID 2386981 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9].Cl[C:14]1[C:15]2[CH2:25][CH2:24][CH2:23][C:22]3[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=3[C:16]=2[N:17]=[C:18]([NH2:20])[N:19]=1>>[NH2:20][C:18]1[N:19]=[C:14]([NH:1][CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:9])([CH3:11])[CH3:10])[C:15]2[CH2:25][CH2:24][CH2:23][C:22]3[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=3[C:16]=2[N:17]=1

参加物

3

反応物 2

HCID 2735700tert-Butyl (3-aminopropyl)carbamateHCID 866218984-chloro-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine

生成物 1

HCID 68603502tert-butyl 3-[(2-amino-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-4-yl)amino]propylcarbamate

実験手順

tert-Butyl 3-aminopropylcarbamate (120 mg, 0.690 mmol) and the product from Example 1C (113 mg, 0.460 mmol) were treated under the conditions described in Example 1D to afford the title compound. 1H NMR (300 MHz, CDCl3) δ ppm 1.47 (s, 9H) 1.65-1.81 (m, 2H) 2.06-2.27 (m, 4H) 2.58 (t, J=6.74 Hz, 2H) 3.22 (q, J=5.95 Hz, 2H) 3.56 (q, J=6.08 Hz, 2H) 4.93 (s, 2H) 5.47-5.76 (m, 2H) 7.16-7.23 (m, 1H) 7.28-7.40 (m, 2H) 7.64-7.71 (m, 1H); MS (ESI+) m/z 384.1 (M+H)+.

出典と根拠

ORDレコード
ord-8744bd3136e5426cbb7b8c839ea754a3
出典データセット
uspto-grants-2012_09
特許番号
US08268846B2

反応ノート

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