N4-(2-aminoethyl)pyrimidine-2,4-diamine dihydrochloride → N4-{2-[(2-aminopyrimidin-4-yl)amino]ethyl}-8-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidine-2,4-diamine

HRID 2386998ノート

反応式

HRID 2386998 の反応式
CC1C=CC(S(O[C:12]2[C:13]3[CH2:23][CH2:22][CH2:21][CH:20]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:19][C:14]=3[N:15]=[C:16]([NH2:18])[N:17]=2)(=O)=O)=CC=1.Cl.Cl.[NH2:32][CH2:33][CH2:34][NH:35][C:36]1[CH:41]=[CH:40][N:39]=[C:38]([NH2:42])[N:37]=1>>[NH2:42][C:38]1[N:37]=[C:36]([NH:35][CH2:34][CH2:33][NH:32][C:14]2[C:13]3[CH2:23][CH2:22][CH2:21][CH:20]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:19][C:12]=3[N:17]=[C:16]([NH2:18])[N:15]=2)[CH:41]=[CH:40][N:39]=1

参加物

3

反応物 2

HCID 86638141N4-(2-aminoethyl)pyrimidine-2,4-diamine dihydrochlorideHCID 866381472-amino-8-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-4-yl 4-methylbenzenesulfonate

生成物 1

HCID 44609257N4-{2-[(2-aminopyrimidin-4-yl)amino]ethyl}-8-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidine-2,4-diamine

実験手順

The product from Example 11C (102 mg, 0.248 mmol) and the product from Example 1E (73 mg, 0.323 mmol) were treated under the conditions of Example 1F to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.09-1.29 (m, 2H) 1.70-2.02 (m, 3H) 2.22-2.63 (m, 2H) 2.71 (dd, J=15.47, 5.16 Hz, 1H) 3.06-3.27 (m, 2H) 3.34-3.50 (m, 3H) 5.56-5.65 (m, 2H) 5.70-5.78 (m, 1H) 5.87 (s, 2H) 6.52 (s, 1H) 6.90 (s, 1H) 7.10-7.34 (m, 5H) 7.61 (d, J=5.55 Hz, 1H); MS (ESI+) m/z 391.1 (M+H)+.

出典と根拠

ORDレコード
ord-b31c51eafd6c4c01a94449fe2732ed3b
出典データセット
uspto-grants-2012_09
特許番号
US08268846B2

反応ノート

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