6-Chloro-8-oxa-3,5-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),3,5,10,12-hexaene → N4-[2-([1]benzofuro[3,2-d]pyrimidin-4-ylamino)ethyl]pyrimidine-2,4-diamine

HRID 2386999ノート

反応式

HRID 2386999 の反応式
Cl[C:2]1[C:3]2[O:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[C:4]=2[N:5]=[CH:6][N:7]=1.Cl.Cl.[NH2:17][CH2:18][CH2:19][NH:20][C:21]1[CH:26]=[CH:25][N:24]=[C:23]([NH2:27])[N:22]=1>>[N:5]1[C:4]2[C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[O:10][C:3]=2[C:2]([NH:17][CH2:18][CH2:19][NH:20][C:21]2[CH:26]=[CH:25][N:24]=[C:23]([NH2:27])[N:22]=2)=[N:7][CH:6]=1

参加物

3

反応物 2

HCID 6092956-Chloro-8-oxa-3,5-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),3,5,10,12-hexaeneHCID 86638141N4-(2-aminoethyl)pyrimidine-2,4-diamine dihydrochloride

生成物 1

HCID 44609562N4-[2-([1]benzofuro[3,2-d]pyrimidin-4-ylamino)ethyl]pyrimidine-2,4-diamine

実験手順

4-Chloro-benzo[4,5]furo[3,2-d]pyrimidine (50 mg, 0.244 mmol) and the product of Example 1E (72 mg, 0.318 mmol) were treated under the conditions of Example 1F to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 3.59-3.85 (m, 4H) 6.03 (d, J=7.12 Hz, 1H) 7.52 (t, J=7.46 Hz, 1H) 7.58-7.67 (m, 1H) 7.67-7.88 (m, 4H) 8.11 (d, J=7.12 Hz, 1H) 8.28-8.44 (m, 1H) 8.82 (t, J=5.43 Hz, 1H) 11.69 (s, 1H); MS (ESI+) m/z 322.0 (M+H)+.

出典と根拠

ORDレコード
ord-5bec58ecc754492f840980aee74bef58
出典データセット
uspto-grants-2012_09
特許番号
US08268846B2

反応ノート

読み込み中…