Hydrochloric Acid → 4-Bromofuran-2-carboxylic acid

HRID 238718ノート

反応式

HRID 238718 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([OH:10])=[O:9])[O:5][C:6]=1Br.[OH-].[NH4+].Cl>[Zn].O>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([OH:10])=[O:9])[O:5][CH:6]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 41948324,5-Dibromofuran-2-carboxylic acid

生成物 1

HCID 122394464-Bromofuran-2-carboxylic acid収率 83.1%

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 962Water溶媒

実験手順

A mixture of 4,5-dibromo-furan-2-carboxylic acid 22a (5.5 g, 20.3 mmol) and 18 mL of ammonium hydroxide was added to 63 mL of water followed by addition of zinc powder (1.46 g, 22.33 mmol). Upon completion of the addition, the reaction mixture was stirred at room temperature for 6 hours. The mixture was adjusted to pH 3 with 1 M hydrochloric acid to form a great quantity of precipitates. The mixture was filtered and the filter cake was washed with n-hexane (15 mL×4) and dried to obtain the title compound 4-bromo-furan-2-carboxylic acid 22b (3.2 g, yield 83.1%) as a white solid.

後処理

  1. additionUpon completion of the addition
  2. customto form a great quantity
  3. customof precipitates
  4. filtrationThe mixture was filtered
  5. washthe filter cake was washed with n-hexane (15 mL×4)
  6. customdried

出典と根拠

ORDレコード
ord-da297a649124435799ac7206f0ba7e33
出典データセット
uspto-grants-2014_02
特許番号
US08642637B2

反応ノート

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