Thiophenol → 5-Chloro-2-pyridinyl phenyl sulfide

HRID 23873

反応式

HRID 23873 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[C:9]1([SH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:9]1([S:15][C:2]2[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

3

反応物 2

HCID 7969ThiophenolHCID 276852,5-Dichloropyridine

生成物 1

HCID 121330785-Chloro-2-pyridinyl phenyl sulfide収率 60.6%

実験手順

2,5 Dichloropyridine (8.9 g, 60 mmol) and thiophenol (6.1 mL, 60 mmol) were heated to 150° C. for 41 h. The mixture then was removed from heat and cooled to room temperature. Column chromatography (silica gel, 200 mL) using hexanes as eluent gave 8.06 g of the title compound; IR (liq.) 1564, 1548, 1476, 1440, 1356, 1122, 1092, 1024, 1006, 821, 748, 727, 706, 691, 628 cm−1. 1H NMR (CDCl3) δ 6.8, 7.4, 7.6, 8.38.

後処理

  1. customThe mixture then was removed
  2. temperaturefrom heat

出典と根拠

ORDレコード
ord-abb631e1a8394b2ab868383dd7c1e0d7
出典データセット
uspto-grants-2005_02
特許番号
US06855709B2

関連ノート

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