5-(benzyloxy)-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-one → 5-hydroxy-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-one

HRID 2387750ノート

反応式

HRID 2387750 の反応式
C([O:8][C:9]1[C:10](=[O:20])[N:11]([CH2:17][O:18][CH3:19])[C:12]([CH3:16])=[N:13][C:14]=1[CH3:15])C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[C].[Pd]>[OH:8][C:9]1[C:10](=[O:20])[N:11]([CH2:17][O:18][CH3:19])[C:12]([CH3:16])=[N:13][C:14]=1[CH3:15]

参加物

5

反応物 2

HCID 672837945-(benzyloxy)-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 672821145-hydroxy-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-one収率 100.1%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

The compound 326-4 (1.42 g) was dissolved in ethyl acetate (30 ml). Palladium-carbon (700 mg) was added to the solution, and the obtained mixture was stirred in a hydrogen atmosphere for 1 hour. The reaction mixture was filtered with Celite, and the filtrate was concentrated under reduced pressure, so as to obtain the crude title compound (954 mg).

後処理

  1. filtrationThe reaction mixture was filtered with Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-5e642718ffdb43dc91d15ba560a443c5
出典データセット
uspto-grants-2012_09
特許番号
US08268848B2

反応ノート

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