Hydrochloric Acid → Methyl 2-(4-(2-(3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propylamino)-2-oxoethyl)phenyl)acetate

HRID 2387823ノート

反応式

HRID 2387823 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:25])[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]([OH:24])=[O:23])=[CH:17][CH:16]=2)=[C:4]([NH:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[N:3]=1.Cl.[CH3:33]O>O1CCOCC1>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:25])[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]([O:24][CH3:33])=[O:23])=[CH:17][CH:16]=2)=[C:4]([NH:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[N:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 68415389{4-[2-({3-[2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl]propyl}amino)-2-oxoethyl]phenyl}acetic acid

生成物 1

HCID 42613075Methyl 2-(4-(2-(3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propylamino)-2-oxoethyl)phenyl)acetate

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

The product from step (i) was dissolved in MeOH (20 mL) then a solution of HCl in dioxane (4M, 0.3 ml) was added and stirred overnight. Solvent was removed and the residue purified by RPHPLC to afford the title compound, 0.032 g.

後処理

  1. customSolvent was removed
  2. customthe residue purified by RPHPLC

出典と根拠

ORDレコード
ord-b385b99588f3421fbad9013a2f95df92
出典データセット
uspto-grants-2012_09
特許番号
US08268990B2

反応ノート

読み込み中…