Carbonic acid-guanidine (1:1) → HCID 178493423、化合物

HRID 2387851ノート

反応式

HRID 2387851 の反応式
[OH:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][CH:7]([C:13](=O)[CH3:14])[C:8](OCC)=[O:9])=[C:4]([O:18][CH3:19])[CH:3]=1.C(=O)(O)O.[NH2:24][C:25]([NH2:27])=[NH:26]>CCO>[NH2:27][C:25]1[N:26]=[C:8]([OH:9])[C:7]([CH2:6][C:5]2[CH:16]=[CH:17][C:2]([OH:1])=[CH:3][C:4]=2[O:18][CH3:19])=[C:13]([CH3:14])[N:24]=1

参加物

4

反応物 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 68415133Ethyl 2-(4-hydroxy-2-methoxybenzyl)-3-oxobutanoate

生成物 1

HCID 178493423HCID 178493423、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of the product from step (ii) (23.35 g) and guanidine carbonate (15.9 g) in EtOH (300 ml) was heated under reflux for 24 h. The mixture was cooled and the solid filtered and washed with EtOH, water, EtOH then diethyl ether and dried to afford the subtitle compound, 11.36 g.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 24 h
  3. temperatureThe mixture was cooled
  4. filtrationthe solid filtered
  5. washwashed with EtOH, water, EtOH
  6. dry with materialdiethyl ether and dried

出典と根拠

ORDレコード
ord-5556f0b6ab3045b69709ac0ecf8a097e
出典データセット
uspto-grants-2012_09
特許番号
US08268990B2

反応ノート

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